Modelling gene expression of Hes1 protein

Prelegent(ci)

Agnieszka Bartłomiejczyk

Afiliacja

Politechnika Gdańska

Termin

29 kwietnia 2015 14:15

Pokój

p. 4050

Seminarium

Seminarium Zakładu Biomatematyki i Teorii Gier

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We analyze a model of gene transcription and protein synthesis and we investigate the effect of multiple binding sites in the Hes1 promoter.
Hes1 protein, a transcriptional repressor, inhibits its own transcription
by directly binding to its own promoter, which blocks transcription of hes1 mRNA. When the transcription of Hes1 mRNA is repressed by this negative feedback, Hes1 protein soon disappears because it is rapidly degraded by the ubiquitin-proteasome pathway. This is joint work with Marek Bodnar.

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