Cellular senescence — a key player in radiotherapy and radiation induced bystander effect?

Prelegent(ci)

Jan Poleszczuk

Afiliacja

MISDoMP Uniwersytet Warszawski

Termin

13 marca 2013 16:15

Pokój

p. 5820

Seminarium

Seminarium Zakładu Biomatematyki i Teorii Gier

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I'm going to present a novel biological hypothesis which combines two hitherto distinct phenomena: cellular senescence and radiation induced bystander effects. Hypothesis gives a new insight into the principles governing the tumor response to ionizing radiation and provides elegant explanation for the various types of bystander effects. Basic analysis based on a mathematical models reveals that the radiation-dose survival curves, and hence the tumor cure probabilities are highly dependent on the amount of cellular senescence triggered by the ionizing radiation or by the bystander signals.

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