Nie jesteś zalogowany |
Quantifying immune receptor diversity.
- Prelegent(ci)
- Aleksandra Walczak
- Afiliacja
- Laboratoire de Physique Théorique, Ecole Normale Supérieure
- Termin
- 6 marca 2013 10:30
- Pokój
- p. 5820
- Seminarium
- Seminarium „Biologia obliczeniowa i bioinformatyka”
Recognition of pathogens relies on the diversity of immune receptor
proteins. Recent experiments that sequence the entire immune cell
repertoires provide a new opportunity for quantitative insight into
naturally occurring diversity and how it is generated. The
generation process is implemented via a series of stochastic molecular
events involving gene choices and random nucleotide insertions
between, and deletions from, genes. I will describe how we can
attempt to quantify the diversity of the receptors formed in this
complex process and point to the origins of diversity in these
sequences.
proteins. Recent experiments that sequence the entire immune cell
repertoires provide a new opportunity for quantitative insight into
naturally occurring diversity and how it is generated. The
generation process is implemented via a series of stochastic molecular
events involving gene choices and random nucleotide insertions
between, and deletions from, genes. I will describe how we can
attempt to quantify the diversity of the receptors formed in this
complex process and point to the origins of diversity in these
sequences.
