Mathematical modelling of the influence of heat shock proteins on cancer invasion of tissue
- Prelegent(ci)
- Zuzanna Szymanska
- Afiliacja
- ICM UW
- Termin
- 28 maja 2008 16:15
- Pokój
- p. 5840
- Seminarium
- Seminarium Zakładu Biomatematyki i Teorii Gier
Tumour cell invasion is crucial for cancer metastasis, which is the main cause
of cancer mortality. An important group of proteins involved in cancer invasion
are the Heat Shock Proteins (HSPs). According to experimental data, inhibition
of one of these proteins, Hsp90, slows down cancer cells while they are
invading tissue. To test different biological hypotheses regarding how
precisely Hsp90 influences tumour invasion, we use a model of solid tumour
growth which accounts for the interactions between Hsp90 dynamics and the
migration of cancer cells and, alternatively, between Hsp90 dynamics and the
synthesis of matrix degrading enzymes (MDEs). The model consists of a system of
reaction-diffusion-taxis partial differential equations describing interactions
between cancer cells, MDE, and the host tissue (ECM). Using numerical
simulations we investigate the effects of the administration of Hsp90
inhibitors on the dynamics of tumour invasion.