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Angiogenesis and chemotherapy resistance: optimizing chemotherapy scheduling using mathematical modeling

Prelegent(ci)
Mariusz Bodzioch
Afiliacja
Uniwersytet Warmińsko-Mazurski w Olsztynie
Termin
5 maja 2021 12:15
Informacje na temat wydarzenia
Zoom Meeting https://us02web.zoom.us/j/83632151104?pwd=R25GeVZmVS9OWXprWDJBbm9FQ0h3dz09
Seminarium
Seminarium Zakładu Biomatematyki i Teorii Gier

Chemotherapy remains a widely used cancer treatment. Acquired drug resistance may greatly reduce the efficacy of treatment and means to overcome it are a topic of active discussion among researchers. One of the proposed solutions is to change the therapeutic target to maintenance rather than complete eradication of cancer, i.e. to treat it as a chronic disease. Using mathematical modeling and optimal control techniques we would like to investigate the hypothesis that lower doses of chemotherapy may be beneficial for patients. We formulate a mathematical model of tumor growth under angiogenic signaling based on Hahnfeldt et al. model, which we adapt to heterogeneous tumors treated by combined anti-angiogenic agent and chemotherapy. Our analysis offers insights into the effects of metronomic therapy. We will discuss our recent results, where the chemotherapy-sensitive cells are killed by the drug according to the log-kill hypothesis and a modification of the model, where the Norton-Simon hypothesis is applied.