A mathematical model describes the malignant transformation of low grade gliomas

Gliomas are the most frequent type of primary brain tumours. Low grade gliomas (LGGs) may grow very slowly for long periods of time, however they inevitably cause death due to the phenomenon known as the malignant transformation. This refers to the  transition of LGGs to more aggressive forms of high grade gliomas  (HGGs). We propose a mathematical model describing the spatio-temporal  evolution of LGGs into HGGs. We showed that the proposed model well  describes real patients’ data. We discuss the relationship between patient prognosis and model parameters and propose estimates  describing tumour evolution up to the onset of malignant  transformation.