Modelling gene expression of Hes1 protein

Speaker(s)

Agnieszka Bartłomiejczyk

Affiliation

Politechnika Gdańska

Date

April 29, 2015, 2:15 p.m.

Room

room 4050

Seminar

Seminar of Biomathematics and Game Theory Group

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We analyze a model of gene transcription and protein synthesis and we investigate the effect of multiple binding sites in the Hes1 promoter.
Hes1 protein, a transcriptional repressor, inhibits its own transcription
by directly binding to its own promoter, which blocks transcription of hes1 mRNA. When the transcription of Hes1 mRNA is repressed by this negative feedback, Hes1 protein soon disappears because it is rapidly degraded by the ubiquitin-proteasome pathway. This is joint work with Marek Bodnar.

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