Mathematical modelling of the influence of heat shock proteins on cancer invasion of tissue

Speaker(s)

Zuzanna Szymanska

Affiliation

ICM UW

Date

May 28, 2008, 4:15 p.m.

Room

room 5840

Seminar

Seminar of Biomathematics and Game Theory Group

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Tumour cell invasion is crucial for cancer metastasis, which is the main cause of cancer mortality. An important group of proteins involved in cancer invasion are the Heat Shock Proteins (HSPs). According to experimental data, inhibition of one of these proteins, Hsp90, slows down cancer cells while they are invading tissue. To test different biological hypotheses regarding how precisely Hsp90 influences tumour invasion, we use a model of solid tumour growth which accounts for the interactions between Hsp90 dynamics and the migration of cancer cells and, alternatively, between Hsp90 dynamics and the synthesis of matrix degrading enzymes (MDEs). The model consists of a system of reaction-diffusion-taxis partial differential equations describing interactions between cancer cells, MDE, and the host tissue (ECM). Using numerical simulations we investigate the effects of the administration of Hsp90 inhibitors on the dynamics of tumour invasion.

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