"Challenges in silico: modelling delays, death and repair in EMT6/Ro tumor cells under a variety of multi-dose irradiation protocols"
- Speaker(s)
- Simon Angus
- Affiliation
- Monash University
- Date
- Oct. 9, 2013, 2:15 p.m.
- Room
- room 5840
- Seminar
- Seminar of Biomathematics and Game Theory Group
Abstract: In silico (computational) techniques offer the potential to
investigate efficiently many aspects of tumour development and
progression. In particular, a calibrated, dynamic, in silico tumour
model could be used to probe the combinatorially extensive, and largely
unexplored, irradiation protocol space (dose size and timing sequence)
in a facile way, with the potential to discover large gains in efficacy
within a given total dose envelope, meriting further clinical
investigation. However, to do this, the tumour model must present
realistic delay, death and repair dynamics under multi-dose irradiation.
Given that the exact mechanism of repair, cell cycle delay and death is
not perfectly understood, the calibration approach itself allows for
the testing of various theoretical assumptions. Our study, building on
our previous work with single-dose irradiation (Angus & Piotrowska,
2013), finds that delay--death--repair dynamics are well represented by a
reciprocal repair function (Fowler, 1999 & 2002) which includes an
unrepairable cell fraction (Carabe-Fernandez, 2001).