Bayesian model for genome-wide prediction of tissue-specific gene expression

Speaker(s)

Bartek Wilczyński (MIM)

Affiliation

Uniwersytet Warszawski

Date

Nov. 9, 2012, 12:15 p.m.

Information about the event

3

Seminar

Seminar Mathematical Models of Gene Expression and Regulatory Networks

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Wspólne seminarium badawcze IPPT i MIMUW.

I will discuss a new probabilistic approach to predict tissue specific expression genome wide.  We use a Bayesian approach to find model parameters maximizing the likelihood based on genome wide data on Transcription Factor binding and gene expression. The model takes into account 3 different levels: transcription factors, enhancers and
promoters. We will show the resulting model is capable of accurate predictions of new tissue-specifically expressed genes in Drosophila mesoderm development.

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