Modeling of the JAK-STAT signaling pathway activated by Interferons type I and type II

Speaker(s)

Małgorzata Kardyńska

Affiliation

Politechnika Śląska

Date

April 27, 2022, 12:15 p.m.

Information about the event

4060 oraz https://us02web.zoom.us/j/84415422061?pwd=S05FckRYODV0ZU42aTBXZnhVdmFwUT09

Seminar

Seminar of Biomathematics and Game Theory Group

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The JAK-STAT signaling pathway regulates the expression of numerous genes related primarily to the immune response and is activated by cytokines, mainly Interferons (IFN) and Interleukins (IL). I will present our original model of the JAK-STAT signaling pathway activated by interferons type I (IFN-α, IFN-β) and type II (IFN-γ). In the model, we proposed a novel negative regulation mechanism based solely on phosphatases. The model was developed based on experimental data for macrophages.

 

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