Cellular senescence — a key player in radiotherapy and radiation induced bystander effect?

Speaker(s)

Jan Poleszczuk

Affiliation

MISDoMP Uniwersytet Warszawski

Date

March 13, 2013, 4:15 p.m.

Room

room 5820

Seminar

Seminar of Biomathematics and Game Theory Group

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I'm going to present a novel biological hypothesis which combines two hitherto distinct phenomena: cellular senescence and radiation induced bystander effects. Hypothesis gives a new insight into the principles governing the tumor response to ionizing radiation and provides elegant explanation for the various types of bystander effects. Basic analysis based on a mathematical models reveals that the radiation-dose survival curves, and hence the tumor cure probabilities are highly dependent on the amount of cellular senescence triggered by the ionizing radiation or by the bystander signals.

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