A Calibrated Cellular Automata Model of in vitro Cultivated Multicellular Tumour Spheroids

Speaker(s)

Monika Joanna Piotrowska

Affiliation

Uniwersytet Warszawski

Date

Oct. 10, 2007, 4:15 p.m.

Room

room 5840

Seminar

Seminar of Biomathematics and Game Theory Group

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SEMINARIUM WSPÓLNE Z SEMINARIUM RTN. In this paper we present a quasi-two dmimensional Cellular Automata (CA)model describing the dynamics of the in vitro cultivated multicellular spheroid obtained from EMT6/Ro (mammary carcinoma) cell line. The CA model is coupled to the experimental data and shows extremely good agreement across a wide range of outputs including bulk growth kinetics, necrotic core formation and kinetics and response to environmental glucose levels.

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