A Calibrated Cellular Automata Model of in vitro Cultivated Multicellular Tumour Spheroids

SEMINARIUM WSPÓLNE Z SEMINARIUM RTN. In this paper we present a quasi-two dmimensional Cellular Automata (CA)model describing the dynamics of the in vitro cultivated multicellular spheroid obtained from EMT6/Ro (mammary carcinoma) cell line. The CA model is coupled to the experimental data and shows extremely good agreement across a wide range of outputs including bulk growth kinetics, necrotic core formation and kinetics and response to environmental glucose levels.