Personal Career Development Plan
Dr Philipp Getto one year's stay will be devoted to the development and analysis of mathematical models, algorithms and computer software related to carcinogenesis and cancer population growth using partial differential, integro-differential and integral equations. In particular using his experience in the area of nonlinear structured population models Philipp will be responsible for the design of models for the evolution of the density function for distribution of differentiation of cells leading to the process of carcinogenesis including feedback mechanisms in this process. Analysis of these models using both analytical and simulation tools may improve the understanding of the process of cancer formation and eventually aid prevention in oncology. Moreover cooperating with biologists and clinicians from the Institute of Oncology, branch Gliwice, Philipp will be able to verify the model using data from in vitro experiments on cell lines. The other class of models that are to be analyzed is related to tumor invasion and initiation and to the evolution of metastasis at the molecular level. Both types of models are located in the main task of activity of the Polish Team. The Polish Team co-ordinates Task 1 of the project, i.e. Mathematical modeling and computer simulation at the sub-cellular scale and cellular scale.


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