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Wydział Matematyki, Informatyki i Mechaniki Uniwersytetu Warszawskiego

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Sem. Biomat. i T. Gier

 

Modeling of the JAK-STAT signaling pathway activated by Interferons type I and type II


Prelegent: Małgorzata Kardyńska

2022-04-27 12:15

The JAK-STAT signaling pathway regulates the expression of numerous genes related primarily to the immune response and is activated by cytokines, mainly Interferons (IFN) and Interleukins (IL). I will present our original model of the JAK-STAT signaling pathway activated by interferons type I (IFN-α, IFN-β) and type II (IFN-γ). In the model, we proposed a novel negative regulation mechanism based solely on phosphatases. The model was developed based on experimental data for macrophages.